Stance instability in spinocerebellar ataxia type 6.
Identifieur interne : 000770 ( Main/Exploration ); précédent : 000769; suivant : 000771Stance instability in spinocerebellar ataxia type 6.
Auteurs : Lisa M. Bunn [Royaume-Uni] ; Jonathan F. Marsden ; Paola Giunti ; Brian L. DaySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- physiology : Postural Balance, Posture.
- physiopathology : Spinocerebellar Ataxias.
- Adult, Aged, Female, Humans, Middle Aged.
Abstract
Balance impairment is a principal symptom of cerebellar disease, but is poorly understood partly because subjects with heterogenous cerebellar and extracerebellar lesions have often been studied. Spinocerebellar ataxia type 6 (SCA6) provides an opportunity to understand balance dysfunction associated with a relatively homogenous cerebellar lesion. This study investigated stance instability in SCA6 and how it is affected by varying stance width. Body sway, as well as its directional preponderance and distribution across joints, was measured three-dimensionally in 17 SCA6 and 17 matched healthy control subjects. Subjects stood for 40 seconds on a stable surface with their eyes open and feet positioned at various stance widths (32, 16, 8, 4, and 0 cm). SCA6 subjects swayed faster than controls at every stance width. Decreasing the stance width produced a disproportionate increase in sway speed in SCA6 subjects, compared to controls. Directional preponderance of sway was dependent on stance width, but did not differ between groups. Joint instability was increased by reducing stance width in both groups, but there was greater instability of the ankle joint in the roll plane in the SCA6 group. Measures of global instability correlated strongly with disease severity measured with the Scale for the Assessment and Rating of Ataxia (r = 0.79). The sway characteristics suggest a disruption of sensorimotor processing for balance control in SCA6. The correlation with disease severity implies that balance impairment is a feature of progression of SCA6 clinical syndrome. With stance width standardized, the instability measures employed could provide sensitive, continuous outcome measures of longitudinal or therapeutic change.
DOI: 10.1002/mds.25163
PubMed: 23143967
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000B72
- to stream PubMed, to step Curation: 000B72
- to stream PubMed, to step Checkpoint: 000789
- to stream Ncbi, to step Merge: 003890
- to stream Ncbi, to step Curation: 003890
- to stream Ncbi, to step Checkpoint: 003890
- to stream Main, to step Merge: 000770
- to stream Main, to step Curation: 000770
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stance instability in spinocerebellar ataxia type 6.</title><author><name sortKey="Bunn, Lisa M" sort="Bunn, Lisa M" uniqKey="Bunn L" first="Lisa M" last="Bunn">Lisa M. Bunn</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden, Jonathan F" sort="Marsden, Jonathan F" uniqKey="Marsden J" first="Jonathan F" last="Marsden">Jonathan F. Marsden</name></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name></author><author><name sortKey="Day, Brian L" sort="Day, Brian L" uniqKey="Day B" first="Brian L" last="Day">Brian L. Day</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/mds.25163</idno><idno type="RBID">pubmed:23143967</idno><idno type="pmid">23143967</idno><idno type="wicri:Area/PubMed/Corpus">000B72</idno><idno type="wicri:Area/PubMed/Curation">000B72</idno><idno type="wicri:Area/PubMed/Checkpoint">000789</idno><idno type="wicri:Area/Ncbi/Merge">003890</idno><idno type="wicri:Area/Ncbi/Curation">003890</idno><idno type="wicri:Area/Ncbi/Checkpoint">003890</idno><idno type="wicri:Area/Main/Merge">000770</idno><idno type="wicri:Area/Main/Curation">000770</idno><idno type="wicri:Area/Main/Exploration">000770</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Stance instability in spinocerebellar ataxia type 6.</title><author><name sortKey="Bunn, Lisa M" sort="Bunn, Lisa M" uniqKey="Bunn L" first="Lisa M" last="Bunn">Lisa M. Bunn</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden, Jonathan F" sort="Marsden, Jonathan F" uniqKey="Marsden J" first="Jonathan F" last="Marsden">Jonathan F. Marsden</name></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name></author><author><name sortKey="Day, Brian L" sort="Day, Brian L" uniqKey="Day B" first="Brian L" last="Day">Brian L. Day</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Postural Balance (physiology)</term><term>Posture (physiology)</term><term>Spinocerebellar Ataxias (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term><term>Posture</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Balance impairment is a principal symptom of cerebellar disease, but is poorly understood partly because subjects with heterogenous cerebellar and extracerebellar lesions have often been studied. Spinocerebellar ataxia type 6 (SCA6) provides an opportunity to understand balance dysfunction associated with a relatively homogenous cerebellar lesion. This study investigated stance instability in SCA6 and how it is affected by varying stance width. Body sway, as well as its directional preponderance and distribution across joints, was measured three-dimensionally in 17 SCA6 and 17 matched healthy control subjects. Subjects stood for 40 seconds on a stable surface with their eyes open and feet positioned at various stance widths (32, 16, 8, 4, and 0 cm). SCA6 subjects swayed faster than controls at every stance width. Decreasing the stance width produced a disproportionate increase in sway speed in SCA6 subjects, compared to controls. Directional preponderance of sway was dependent on stance width, but did not differ between groups. Joint instability was increased by reducing stance width in both groups, but there was greater instability of the ankle joint in the roll plane in the SCA6 group. Measures of global instability correlated strongly with disease severity measured with the Scale for the Assessment and Rating of Ataxia (r = 0.79). The sway characteristics suggest a disruption of sensorimotor processing for balance control in SCA6. The correlation with disease severity implies that balance impairment is a feature of progression of SCA6 clinical syndrome. With stance width standardized, the instability measures employed could provide sensitive, continuous outcome measures of longitudinal or therapeutic change.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Day, Brian L" sort="Day, Brian L" uniqKey="Day B" first="Brian L" last="Day">Brian L. Day</name><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><name sortKey="Marsden, Jonathan F" sort="Marsden, Jonathan F" uniqKey="Marsden J" first="Jonathan F" last="Marsden">Jonathan F. Marsden</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bunn, Lisa M" sort="Bunn, Lisa M" uniqKey="Bunn L" first="Lisa M" last="Bunn">Lisa M. Bunn</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000770 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000770 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23143967
|texte= Stance instability in spinocerebellar ataxia type 6.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23143967" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |